Process for the preparation of 1-pyridyl-alkyl-4-aryl...

Details Process for the preparation of 1-pyridyl-alkyl-4-aryl... Process for the preparation of 1-pyridyl-alkyl-4-aryl...

C - Chemistry, Metallurgy

07

D

260/266.3

C07D 401/06 (2006.01) C07D 213/36 (2006.01)

Patent

CA 1256108

ABSTRACT A process for the preparation of 1-pyridyl-alkyl-4- aryl piperazines, in the racemic form, of the formula Image (I) in which: the pyridine ring is alpha-, beta-, or gamma-pyridyl R = H: CnH2n+1, n being in the range from 1 to 4; R' = H; halogen, CH3, OCH3, in which process: a) pyridine aldehyde is reacted between -5°C and 0°C with (CH3)2S=CH2; b) the oxirane so obtained is treated with an arylpiperazine; c) the hydroxyl derivative obtained in b), after salifi- cation with alkaline hydrides or hydroxides in a solvent medium is treated with alkylating agents, and the separation of the compounds so obtained into the respect- ive optical antipodes.

458335

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