C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/556.7
C07C 233/25 (2006.01) A01N 37/18 (2006.01) A01N 37/22 (2006.01) A01N 37/26 (2006.01)
Patent
CA 1130317
ABSTRACT OF THE DISCLOSURE The invention relates to an improved method for the preparation of a 2',6'-dialkyl-N-alkoxymethyl-2-chloro-acetanilide conpound of the general formula (I), Image (I) wherein R1, R2 and R3 are identical or different and stand for straight-chained or branched C1-4 alkyl groups. According to the invention a dialkyl aniline of the general formula (II), Image (II) wherein R1 and R2 are as defined above, is treated with aqueous formaldehyde solution in an apolar solvent at a temperature of 30 to 80°C, the solution of the resulting oxymethyl derivative formed with said apolar solvent is separ- ated from the aqueous formaldehyde solution at an elevated temperature and then dehydrated, the resulting azomethine derivative is reacted with chloro- acetyl chloride in the same apolar solvent medium, the resulting chloromethyl compound is reacted with an alcohol of the general formula (V), R3-OH (V) wherein R3 is as defined above, in an amount sufficient to bind the hydro- chloric acid liberated in the reaction, the reaction mixture is admixed with water, and the organic phase containing tne required end-product is separated and optionally processed.
344036
Domjan Kornelia Nee Pinter
Gyorfi Bela
Haas Andras
Huszak Gyorgy
Kolonics Zoltan
Fetherstonhaugh & Co.
Mta Mezogazdasagi Kutato Intezet
Nehezvegyipari Kutato Intezet
Nitrokemia Ipartelepek
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