C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 33/08 (2006.01) C07J 7/00 (2006.01)
Patent
CA 2637731
The invention relates to the use of bacterial strains of the species Amycolatopsis mediterranei for the microbial transformation of 9.beta.,10.alpha.-steroids of general Formula (I) to their corresponding 11.beta.-hydroxyl analogues, as well as to specific strains of that species. In addition, the present invention relates to the process of transforming 9.beta.,10.alpha.-steroids to their corresponding 11.beta.-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and to the subsequent isolation of the 11.beta.-hydroxyl derivatives from the bacterial culture medium. The resultant 11.beta.- hydroxylated products are useful intermediates for the preparation of novel steroidal compounds with 9.beta.,10.alpha.-confirmation carrying different kind of substituents in the 11.beta.-position.
La présente invention concerne l'utilisation de souches bactériennes de l'espèce Amycolatopsis mediterranei pour la transformation microbienne de stéroïdes 9.beta.,10.alpha. de formule générale (I) en leurs analogues 11.beta.-hydroxyle correspondants, ainsi que des souches spécifiques de cette espèce. L'invention concerne également un procédé de transformation des stéroïdes 9.beta.,10.alpha. en leurs dérivés 11.beta.-hydroxyle correspondants en utilisant des souches bactériennes de l'espèce Amycolatopsis mediterranei et l'isolement ultérieur des dérivés 11.beta.-hydroxyle à partir du milieu de culture bactérien. Les produits hydroxylés en 11.beta. résultants sont des intermédiaires utilisables dans la préparation de composés stéroïdiens innovants avec une confirmation 9.beta.,10.alpha. portant divers types de substituants en position 11.beta..
Hakala Juha
Messinger Josef
Rasche Heinz-Helmer
Schmidt Michael
Thole Heinrich-Hubert
Mccarthy Tetrault Llp
Solvay Pharmaceuticals Gmbh
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