Process for the preparation of...

Details Process for the preparation of... Process for the preparation of...

C - Chemistry, Metallurgy

07

D

260/294

C07D 211/70 (2006.01)

Patent

CA 1041516

ABSTRACT OF THE DISCLOSURE A process for the preparation of 1,3,4-trimethyl-2- (3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridine of formula Image I which comprises subjecting 1,3,4-trimethyl-(3,4,5-trimethoxy- benzyl)-1,2,5,6-tetrahydropyridine of formula Image II to a Stevens rearrangement in the presence of a solution of phenyl-lithium in ether under reflux of the reaction mixture, and, if desired, converting the compound of formula I produced into an addition salt thereof with a pharmaceutically acceptable acid, for example hydrochloric acid.

226058

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