C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 17/00 (2006.01) C07J 7/00 (2006.01) C07J 33/00 (2006.01) C07J 43/00 (2006.01) C07J 71/00 (2006.01)
Patent
CA 2258681
The invention provides an improved process for the preparation of 17-esters of 9.alpha.,21-dihalo-pregnane-11.beta.,17.alpha.-diol-20-ones, and in particular for the preparation of 17-esters of anti-inflammatory steroids according to the above-mentioned scheme, wherein RCO, R1, X, Y and the dotted line are as defined in the specification. The novel process is especially suitable for the preparation of Mometasone Furoate.
L'invention concerne un procédé amélioré de préparation de 17-esters de 9 alpha ,21-dihalo-pregnane-11 beta ,17 alpha -diol-20-ones, et en particulier la préparation de 17-esters de stéroïdes anti-inflammatoires selon le schéma représenté par la figure où RCO, R<1>, X, Y et la ligne en pointillés sont tels que définis dans la description. Ce nouveau procédé est particulièrement approprié à la préparation de mometasone furoate.
Fu Xiaoyong
Kwok Daw-Iong Albert
Tann Chou-Hong
Tsai David J.s.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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