C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/06 (2006.01)
Patent
CA 2439319
The present invention relates to the preparation of (E)-5-(2-bromovinyl)-2'- deoxyuridine (Brivudine) characterized in that halogen-free solvents selected form esters or cyclic ethers are used in the bromination step of 5-ethyl-2'-deoxyuridine diacylate. The use of said solvents is advantageous in respect of toxicity, discharge costs and environment protection.
La présente invention se rapporte à la préparation de (E)-5-(2-bromovinyl)-2'-désoxyuridine (Brivudine) qui se caractérise en ce que des solvants ne contenant pas d'halogène sélectionnés parmi des esters ou des éthers cycliques sont utilisés au cours de l'étape de bromation du diacylate de 5-éthyl-2'-désoxyuridine. Ces solvants sont avantageux du fait de leur faible toxicité, de leur aspect écologique et des coûts réduits de décharge qui leur sont associés.
Maggi Carlo Alberto
Manzini Stefano
Salimbeni Aldo
Turozzi Damiano
Berlin-Chemie Ag
Kirby Eades Gale Baker
Menarini Ricerche S.p.a.
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