Process for the preparation of 1h-azole derivatives

C - Chemistry – Metallurgy – 07 – D

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260/305, 260/304

C07D 317/08 (2006.01) C07D 405/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1154773

Abstract of the Disclosure An improved process for the preparation of 2-tert.-butyl-2-(1-phenoxy- 1-(1H-azol-1-yl)]-methyl-ketales of the formula Image wherein X represents -CH= or -N=; R1, R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, lower alkyl, cyano, methoxy, phenyl and nitro; A represents -CH(R4)-CH(R5)- or -CH2-C(R6)(R7)-CH2-; R4 and R5 are each independently selected from the group consisting of hydrogen, C12-C6-alkyl, C1-C6-alkoxymethyl and phenoxymethyl or said substituents R4 and R5 form together a tetramethylene group; and R6 and R7 are each independently selected from the group consisting of hydrogen and lower alkyl, which process comprises reacting a 2-tert.-butyl-2-[1-phenoxy-1- halo]-methyl-ketale with a quaternary ammonium or phosphonium salt of an azole. The azoles used are 1H-1,2,4-triazole or 1H-imidazole.

367087

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