Process for the preparation of [(1r), 2s]-2-aminopropionic...

Details Process for the preparation of [(1r), 2s]-2-aminopropionic... Process for the preparation of [(1r), 2s]-2-aminopropionic...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01)

Patent

CA 2650059

The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: (I). Compound (I) has been shown to be useful for the treatment of certain types of cancer.

La présente invention concerne un procédé amélioré de synthèse du [(1R),2S]-2-aminopropionate de 2-[4-(4-fluoro-2-méthyl-1H-indol-5-yloxy)-5-méthylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-méthyléthyle de formule : (I). Il a été démontré que le composé (I) pouvait être employé dans le traitement de certains types de cancers.

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