C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/367.3
C07D 307/52 (2006.01) A61K 31/34 (2006.01) C07D 307/38 (2006.01)
Patent
CA 1177491
ABSTRACT A new process for the preparation of 2-[[[5-(dimethyl- aminol-methyl-2-furany] methy] thio]ethaneamine of the formula Image is described, wherein 2-[[[5-(dimethylamino)methyl-2-furany] - methyl] thio]ethanol of the formula Image is halogenated to the corresponding halogenide of the formula Image wherein Hal is chlorine or bromine, and the resulting compound is aminated with ammonia to yield the desired compound. The desired compound represents a valuable intermediate for the preparation of the therapeutically important compound ranitidine, which is used for the treatment of ulcer diseases.
429776
Hribar-Kikelj Alenka
Lah Jolanda
Zmitek Janko
Borden Ladner Gervais Llp
N.sol.o Lek Tovarna Farmacevtskih In Kemicnih Izdelkov
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