Process for the preparation of 2-alkoxy-n-(1-...

Details Process for the preparation of 2-alkoxy-n-(1-... Process for the preparation of 2-alkoxy-n-(1-...

C - Chemistry, Metallurgy

07

D

260/272

C07D 453/02 (2006.01)

Patent

CA 1288776

PROCESS FOR THE PREPARATION OF 2-ALKOXY-N-(1-AZABICYCLO[2.2.2]OCTAN-3-YL) AMINOBENZAMIDES ABSTRACT OF THE INVENTION A process for the preparation of 2-alkoxy-N-(1- azabicyclo[2.2.2]octan-3-yl)aminobenzamides, which are gastric pharmaceuticals in monogastric animals having the formula: Image wherein R is hydrogen or loweralkyl, R1 is loweralkyl, R2 is hydrogen, halo or loweralkoxy, Am is amino, methylamino or dimethylamino is disclosed wherein in the initial step an appropriate monoprotonated 3-aminoquinuclidine stromg acid salt and an appropriate amino benzonic acid all in a 50-90 vol. % pyridine in water solution are reacted in the presence of N,N'-dialkylcarbodiimide. The free base may be obtained by conventional procedures from the mixtures with minimal purification effort.

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