Process for the preparation of 2-arylpropionic acids

Details Process for the preparation of 2-arylpropionic acids Process for the preparation of 2-arylpropionic acids

C - Chemistry, Metallurgy

12

P

195/131

C12P 41/00 (2006.01) C12N 9/18 (2006.01) C12P 7/40 (2006.01) C12P 17/00 (2006.01)

Patent

CA 1340382

A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula (see fig. I) or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula (see fig. II) wherein R2 is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof.

526796

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