C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/251, 260/248
C07D 241/52 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 1154770
ABSTRACT The invention relates to a process for the prapara- ion of 2-methylene-1,4-dioxide derivatives of the general formula /I/ Image wherein A represents a hydroxyl or an amino group, or a group of the general formula -NH-COOR1, wherein R1 denotes a C1-4 alkyl group; or a group of the general formula -NH-CX-NH2, wherein X stands for oxygen or sulfur; or a group of the formula -NH-C/=NH/-NH2; or a group of the general formula -NH-R2, wherein R2 represents C1-6 alkyl, ohenyl, benzyl, hydroxyl or hydroxy-/C2-4 alkyl/; or a group of the general formula -NH-CO-R3, wherein R3 stands for a C1-20 alkyl group, a phenyl group optionally substituted by one, tno or three identical or different substituent/s/ selected from the group consisting of hydroxyl, amino, nitro, C1-4 alkyl, C1-4 alkoxy or halogen; a piperidyl, a pyridyl, a furyl, a nitro- furyl, a pyrazinyl, a pyrimidyl, a naphthyl, a hydroxy- naphthyl, a phenylalkyl, an 1,2,4-triazinyl, an .alpha.,.alpha.- -diphenyl-.alpha.-hydroxymethyl, a cyanomethyl, a halomethyl -2- or a hydroxymethyl group, characterized by dehydrating a compound of the general formula /II/ Image wherein A has the same meanings as above. The compounds of the general formula /I/ possessing bactericidal and weight-gain increasing properties can be obtained in a high purity with an excellent yield by the process according to the invention.
385733
Balogh Albert
Benko Pal
Kovacs Jeno
Magyar Karoly
Matrai Erzsebet
Egyt Gyogyszervegyeszeti Gyar
Fetherstonhaugh & Co.
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