Process for the preparation of 2-nitro-5-fluoro- or...

C - Chemistry – Metallurgy – 07 – C

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C07C 205/22 (2006.01) C07C 205/26 (2006.01)

Patent

CA 2080208

HOE 91/F 318 Abstract of the Disclosure: Process for the preparation of 2-nitro-5-fluoro- or -5- chlorophenol The present invention relates to a process for the preparation of isomerically pure 2-nitro-5-fluoro- or -5- chlorophenol, by reacting 2,4-difluoronitrobenzene or 2,4-dichloronitrobenzene with aqueous alkali metal or alkaline earth metal hydroxide solution or suspension in the absence of organic solvents or other solubility promoting substances at temperatures from about 20°C to about 190°C, adjusting the pH of the reaction mixture to about 1 to about 6 by the addition of acid, steam distilling the resultant product and isolating it from the distillate after cooling.

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