Process for the preparation of 2-substituted...

Details Process for the preparation of 2-substituted... Process for the preparation of 2-substituted...

C - Chemistry, Metallurgy

07

D

C07D 233/96 (2006.01) C07D 233/68 (2006.01)

Patent

CA 2135541

A novel process for the preparation of 2- substituted 5-chloroimidazole-4-carbaldehydes of the general formula: Image wherein R represents hydrogen or an alkyl, alkenyl, cyclo- alkyl, arylalkyl or aryl group, is described. In this process a glycine ester hydrohalide is ring-closed with an imidate ester to give a 2-substituted 3,5-dihydroimidazol-4- one, which is converted into an N,N-substituted amino- methyleneimidazolinone using an N,N-substituted formamide acetal and finally chlorinated. The 5-chloroimidazole-4- carbaldehydes (I) are important intermediates in the preparation of hypotensive pharmaceuticals.

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