C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) C07D 209/30 (2006.01)
Patent
CA 2149286
A process for the preparation of a compound of the formula 1 Image 1 wherein R is hydrogen, loweralkyl, loweralkoxy or trifluoromethyl; R1 is hydrogen or loweralkyl; R2 is loweralkyl; R3 is hydrogen, loweralkyl, loweralkoxy or trifluoromethyl; and m is 1 or 2, which comprises the steps of: (a) contacting a compound of the formula 11 Image 11 wherein R, R1, R2, R3, and m are as above and X is iodo, bromo or chloro with formic acid in the presence of a metal catalyst; and (b) isolating the product. The products produced by the process described have memory enhancing, analgetic and antidepressant properties.
Goehring Keith E.
Lee Thomas B.
Aventis Pharmaceuticals Inc.
Bereskin & Parr
Hoechst-Roussel Pharmaceuticals Inc.
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