Process for the preparation of...

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C - Chemistry, Metallurgy

07

D

C07D 233/68 (2006.01) A61K 31/4164 (2006.01) C07C 303/40 (2006.01) C07C 311/16 (2006.01) C07C 311/40 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01)

Patent

CA 2456531

Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives of formula I, wherein R1 represents optionally substituted aryl or heteroaryl, which comprises treating a compound of formula II, wherein R1 has the same meaning defined in the formula I and Bu t represents tert-butyl, with an acid. The 4-(imidazol-1-yl)benzenesulfonamide derivatives of formula I are useful as anti-inflammatory agents. (see formula I) (see formula II)

Procédé de préparation de dérivés de 4-(imidazol-1-il)benzènesulfonamide de formule (I), dans laquelle R<1> représente un groupe aryle ou hétéroaryle optionellement substitué. Ce procédé se caractérise par le fait de traiter un composé de formule (II), dans laquelle R<1> a la signification susmentionnée pour la formule (I) et Bu<t >représente tert-butyle, avec un acide. Les dérivés de 4-(imidazol-1- il) benzènesulfonamide de formule (I) son utiles en tant qu'agents anti-inflammatoires.

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