Process for the preparation of...

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C - Chemistry, Metallurgy

07

H

C07H 19/10 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2064723

A process for the preparation of 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate (II) from 9-beta-D-arabinofur- anosyl-2-fluoroadenine (I) by phosphorylation is described. The reaction is conducted under anhydrous conditions, particularly where (I) is dried extensively in a vaccum. The compound (II) is an antileukemia and antiviral drug.

n décrit un procédé pour la préparation de 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate (II) à partir de 9-beta-D-arabinofuranosyl-2-fluoroadenine (I) par phosphorylation. La réaction est effectuée dans des conditions anhydres, particulièrement lorsque (I) est séché à fond sous vide. Le composé (II) est un médicament antileucémique et antiviral.

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