C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 227/32 (2006.01) C07C 231/18 (2006.01) C07C 233/05 (2006.01)
Patent
CA 2656122
This invention relates to the preparation of (R)-(-)-3-(carbamoylmethyl)-5- methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(-)-3-(carbamoylmethyl)-5- methylhexanoic acid into biologically active molecules such as pregabalin.
L'invention concerne la préparation d'acide (R)- (-)-3-(carbamoylméthyl)-5-méthylhexanoïque et, en particulier, la résolution du composé racémique de l'acide au moyen d'une salification par des amines optiquement actives, suivie par une acidification afin d'obtenir l'énantiomère (R) de l'acide. Elle concerne également les sels intermédiaires constitués par lesdites amines et la conversion dudit acide (R)- (-)-3-(carbamoylméthyl)-5-méthylhexanoïque en molécules biologiquement actives, telles que prégabaline.
de Angelis Bruno
Nardi Antonio
Salvi Annibale
Laboratorio Chimico Internazionale S.p.a.
Robic
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