Process for the preparation of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 321/00 (2006.01) C07C 273/18 (2006.01) C07C 275/24 (2006.01) C07D 317/28 (2006.01) C07D 319/06 (2006.01) C07D 405/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2636455

Disclosed is an improved multi-step process for preparing a compound of Formula I and intermediates used therein: (I) wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

La présente invention concerne un procédé amélioré en plusieurs étapes destiné à préparer un composé répondant à la formule I dans laquelle R1 à R3 sont tels que définis dans le présent document. Les composés répondant à la formule I inhibent la liaison entre des molécules d'adhésion intercellulaires humaines et les leucointégrines. En conséquence, ces composés sont utiles dans le traitement de pathologies inflammatoires et médiées par les cellules immunitaires.

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