C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/87 (2006.01)
Patent
CA 2435925
Method for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluoro- phenyl)- 1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) comprising the reaction of a compound of formula (III) wherein X is a halogen, with organometallic dimethylaminopropyl halide. Other aspects of the invention are new compounds of formula (II) and formula (III) and their preparation.
L'invention concerne un procédé de préparation de 1-(3-diméthylaminopropyl)-1-(4-fluorophényl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram), consistant à faire réagir un composé de formule (III) dans laquelle X est un halogène, avec un halogénure de diméthylaminopropyle organométallique. D'autres aspects de l'invention concernent de nouveaux composés de formule (II) et de formule (III) ainsi que leur préparation.
Grumann Arne
Hilden Leif
Huuhtanen Tuomas
Pietikainen Pekka
Rummakko Petteri
Fermion Oy
Orion Corporation Fermion
Robic
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