Process for the preparation of 3,6-disubstituted 4-...

C - Chemistry – Metallurgy – 07 – D

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260/248.6

C07D 253/06 (2006.01) C07D 253/07 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 1180014

ABSTRACT Process for the preparation of 3,6-di- substituted 4-amino-1,2,4-triazin-5-ones The herbicidal 3,6-substituted 4-amino-1,2,4- triazin-5-one of the general formula Image (I) wherein R1 and R2 have the meaning given in the description, is obtained in good yields by a new two-stage cyclis- ation reaction if an .alpha.-ketocarboxylic acid amide of the general formula R1-CO-CO-NHR3 (II) is reacted with a hydrazidine of the general formula Image (III) if appropriate in the presence of a diluent at tempera- tures between 0 and 150°C, whereby in the first process stage a condensation reaction takes place to give con- densation products which still have open chains, and in the second process stage an elimination reaction with ring closure takes place to give the end product of formula (I).

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