Process for the preparation of 3-substituted 7-...

C - Chemistry – Metallurgy – 07 – D

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260/102, 260/108

C07D 501/18 (2006.01) C07D 487/04 (2006.01) C07D 505/00 (2006.01)

Patent

CA 1190543

ABSTRACT OF THE DISCLOSURE A 3-substituted 7-aminocephalosporanic acid of formula: Image where R1 is hydrogen, methyl or methoxy, Y is nitrogen, oxygen sulphur or a sulphoxide group, R2 is a group selected from among azide or from a radical having the formula R3-S- where R3 may be, among others, alkyl, aliphatic acyl, methyl and chlorine or methoxy substituted aromatic acyl, is prepared. A compound of formula Image (X being chlorine, carbamoyloxy or acetoxy) is added to a medium constituted by water, a compound which may be nitric acid or a compound of formula R3-SH and a tertiary organic base, With a reaction isoelectric pH regulator, the mixture take on a specific process pH analytical profile, the compounds of said mixture being reacted together at particular temperatures and with a specific process time. 1.

406046

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