C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) C07D 311/58 (2006.01)
Patent
CA 2445207
The present invention relates to a process for the preparation of 2-[5-(4- fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.
La présente invention concerne un procédé de fabrication de 2-[-5-(4-fluorophényl)-3-pyridylméthylaminométhyl]-chromane, des énantiomères et des sels dudit composé. Le procédé selon l'invention est caractérisé en ce que 5-(4-fluorophényl)-pyridine-3-carbaldéhyde est transformé directement en 2-[-5-(4-fluorophényl)-3-pyridylméthylaminométhyl]-chromane avec aminométhyl-chromane ou ses sels dans des conditions réductrices, et éventuellement transformé en un des sels physiologiquement acceptables par traitement avec un acide.
Bokel Heinz-Hermann
Devant Ralf
Gantzert Ludwig
Helm Udo
Knierieme Ralf
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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