C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2675642
The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4- methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the active entity within AZD0530), to intermediates useful in the manufacture of that compound and to processes for the manufacture of those intermediates. The invention also relates to particular crystalline forms of that compound such as a difumarate salt and a trihydrate and to pharmaceutical compositions containing such crystalline forms.
Ford James Gair
Mccabe James Francis
O'kearney-Mcmullan Anne
O'keefe Philip
Pointon Simon Mark
Astrazeneca Ab
Fetherstonhaugh & Co.
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