C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 7/08 (2006.01)
Patent
CA 2204728
The present invention relates to a novel process for preparing 1-halo-3- trialkylsilanyl-benzenes from 1,3-dihalo-benzenes which are useful intermediates in the preparation of 1-(3-trialkylsilylphenyl)-2,2,2- trifluoromethyl ethanones which are useful for the treatment of Alzheimer's disease and senile dementia.
La présente invention concerne un nouveau procédé pour préparer des 1-halo-3-trialkylsilanyl-benzènes à partir de 1,3-dihalo-benzènes. Les composés de l'invention sont des intermédiaires utiles pour la préparation de 1-(3-trialkylsilylphényl)-2,2,2-trifluorométhyl éthanones qui sont utiles pour le traitement de la maladie d'Alzheimer et de la démence sénile.
Keaten Robert T.
Klipa Dennis K.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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