A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/426 (2006.01) C07D 277/04 (2006.01)
Patent
CA 2644303
The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to novel compounds of 3,4-disubstituted-thiazolidin-2-ones. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds (such as latrunculins and/or their analogs) for treating diseases or conditions associated with inhibiting actin polymerization.
La présente invention concerne des procédés pratiques de synthèse à haut rendement permettant de préparer des thiazolidin-2-ones bi-substitués en 3,4 sans compromettre l'intégrité stéréochimique absolue des composés. L'invention concerne également des composés innovants de thiazolidin-2-ones bi-substitués. Les composés préparés selon la présente invention sont utilisables pour la synthèse et la fabrication de composés (tels que les latrunculines et/ou leurs analogues) destinés au traitement de maladies ou d'affections associées à l'inhibition de la polymérisation de l'actine.
Decamp Jonathan B.
She Jin
Watson Paul S.
Gowling Lafleur Henderson Llp
Inspire Pharmaceuticals Inc.
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