C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/32 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2667679
The present invention relates to a process of the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one of the formula (I) by employing a dialkylmalonate of the formula (V) wherein R1b is lower alkyl, and the use of this process for the manufacture of DPP-IV inhibitors that are useful for the treatment and/or prophylaxis of diseases such as diabetes.
La présente invention porte sur un procédé de préparation de la (S)-4-fluorométhyl-dihydro-furan-2-one de la formule (I) par l'emploi d'un malonate de dialkyle de la formule (V) dans laquelle R1b est alkyle inférieur, et sur l'utilisation de ce procédé pour la fabrication d'inhibiteurs DPP-IV qui sont utiles pour le traitement et/ou la prophylaxie de maladies telles que le diabète.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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