Process for the preparation of...

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C - Chemistry, Metallurgy

07

D

C07D 239/90 (2006.01) C07C 255/54 (2006.01) C07C 255/59 (2006.01) C07D 239/88 (2006.01) C07D 239/94 (2006.01) C07D 295/092 (2006.01)

Patent

CA 2498122

The invention relates to chemical processes and intermediates useful in the manufacture of the quinazoline derivative 4 (3' chloro 4' fluoroanilino)-7- methoxy-6-(3-morpholinopropoxy)quinazoline. In particular, the invention relates to processes for the manufacture of 7-methoxy-6-(3-morpholinopropoxy)- 3,4-dihydroquinazolin-4-one of Formula (II) and 4-methoxy-5-(3- morpholinopropoxy)-2-nitrobenzonitrile of Formula (III) and their use in the manufacture of said quinazoline derivative.

L'invention concerne des procédés chimiques et des intermédiaires utiles dans la fabrication du dérivé de 4 (3'-chloro-4'-fluoroanilino)-7-méthoxy-6-(3-morpholinopropoxy)quinazoline. Plus précisément, l'invention concerne des procédés de fabrication de 7-méthoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one de formule II et de 4-méthoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile de formule III et l'utilisation de ceux-ci dans la fabrication du dérivé de quinazoline.

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