Process for the preparation of 5-(3,4,5-...

Details Process for the preparation of 5-(3,4,5-... Process for the preparation of 5-(3,4,5-...

C - Chemistry, Metallurgy

07

D

260/262.5

C07D 239/49 (2006.01) C07D 239/48 (2006.01)

Patent

CA 1141381

A b s t r a c t Process for the production of Trimethoprim by reaction of 3, 4, 5-tri- methoxybenzoic acid chloride with cyanoacetaldehyde dimethylacetal;the ketonitrile so obtained is allowed to react with a guanidine salt and the reaction product is hydrogenated catalytically.

371183

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