Process for the preparation of 5-arylnicotinaldehydes

Details Process for the preparation of 5-arylnicotinaldehydes Process for the preparation of 5-arylnicotinaldehydes

C - Chemistry, Metallurgy

07

D

C07D 213/48 (2006.01) C07D 213/30 (2006.01) C07D 213/80 (2006.01)

Patent

CA 2399125

The invention relates to a process for the preparation of 5-arylnicotin-aidehydes by reduction of the corresponding 5-aryinicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.

L'invention concerne un procédé permettant de préparer des 5-arylnicotinaldéhydes, par réduction des acides 5-arylnicotiniques par hydrogénation catalytique, en présence d'anhydrides d'acide carboxylique, opération au cours de laquelle le catalyseur utilisé est un complexe palladium-ligand. Ce procédé se caractérise en ce que le rapport molaire du palladium au ligand est de l'ordre de 1 : 5 à 1 : 15 dans le cas de ligands à une dent et de l'ordre de 1 : 2,5 à 1 : 7,5 dans le cas de ligands à deux dents.

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