Process for the preparation of 5-bromo-2-methoxyresorcinol

Details Process for the preparation of 5-bromo-2-methoxyresorcinol Process for the preparation of 5-bromo-2-methoxyresorcinol

C - Chemistry, Metallurgy

07

C

C07C 41/26 (2006.01) C07C 43/23 (2006.01)

Patent

CA 2049172

?8,190-00 AN IMPROVED PROCESS FOR THE PREPARATION OF 5-BROMO-2-METHOXYRESORCINOL ABSTRACT OF THE DISCLOSURE This invention is concerned with an improved process for metallating 2, 4, 6-tribromoanisole 1 and reacting this intermediated lithio species with various electrophiles for example the trialkoxy borates which an example is trimethylborate, the improvement comprising carrying out the reaction under heterogenous conditions. This product is oxidatively converted to the compound 5-bromo-2-methoxy-resorcinol 2, which is in turn converted to the known 2-methoxy-resorcinol 3. The process and intermediate are useful in the synthesis of platelet activating factor antagonist thiazolium, 3-[[3-[[hydroxy[2-methoxy-3-(tetradecyloxy) phenoxy]phosphinyl]oxy]phenyl]methyl]-5-methyl-, hydroxide, inner salt CA of U. S. Patent 4983592 (1991).

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