Process for the preparation of 5-formylphthalide

Details Process for the preparation of 5-formylphthalide Process for the preparation of 5-formylphthalide

C - Chemistry, Metallurgy

07

D

C07D 307/80 (2006.01) C07D 307/88 (2006.01)

Patent

CA 2456005

There is described a process for the preparation of 5-formylphthalide by hydrogenation of a halide of 5-carboxyphthalide, dissolved in a dipolar aprotic solvent, in the presence of a catalyst. Furthermore, the use of 5- formylphthalide in the preparation of citalopram is described.

La présente invention concerne un procédé de préparation de 5-formylphthalide par hydrogénation d'un halogénure de 5-carboxyphthalide, dissous dans un solvant aprotique dipolaire en présence d'un catalyseur. L'invention se rapporte en outre à l'utilisation de 5-formylphthalide dans la préparation de citalopram.

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