Process for the preparation of 5-hydroxymethyl...

Details Process for the preparation of 5-hydroxymethyl... Process for the preparation of 5-hydroxymethyl...

C - Chemistry, Metallurgy

07

D

C07D 263/24 (2006.01) C07D 263/06 (2006.01)

Patent

CA 2418227

A process for preparing 5-hydroxymethyl-2-oxazolidinone (1) , (see formula 1) preferably optically active, in one step from 3,4-boronic acid ester protected 3,4-dihydroxybutyramides (2) is described. The oxazolidinone is important in the pharmaceutical industry especially in the areas of antimicrobials and behavioral disorders.

L'invention concerne un procédé de préparation de 5-hydroxyméthyl-2-oxazolidinone (1), de préférence optiquement active, en une seule étape à partir de 3,4-dihydroxybutyramides (2) protégés par un ester d'acide 3,4-boronique. L'oxazolidinone est importante dans l'industrie pharmaceutique, notamment dans les domaines des antimicrobiens et des troubles du comportement.

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