Process for the preparation of 5-substituted-1,2-...

Details Process for the preparation of 5-substituted-1,2-... Process for the preparation of 5-substituted-1,2-...

C - Chemistry, Metallurgy

07

D

260/299

C07D 487/04 (2006.01) C07D 207/335 (2006.01) C07D 207/337 (2006.01) C07D 333/38 (2006.01)

Patent

CA 1111431

ABSTRACT OF THE DISCLOSURE 5-Substituted-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole- l-carboxylic acids of the formula: Image (I) wherein Y is Image Image Image (IA) (IB) or (IC) in which R is hydrogen, methyl, chloro or bromo, the R substitution being at the 3, 4 or 5 positions of the thiophene ring; R1 is hydrogen, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo, the R1 substitution being at the ortho, meta or para positions of the aroyl group, and R2 is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, are prepared by hydrolysis, from their corresponding nitriles. The compounds of formula I are useful as anti-inflammatory and anelgetic agents and as smooth muscle relaxants.

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