Process for the preparation of 5-substituted 2-chloropyridines

Details Process for the preparation of 5-substituted 2-chloropyridines Process for the preparation of 5-substituted 2-chloropyridines

C - Chemistry, Metallurgy

07

D

C07D 213/61 (2006.01)

Patent

CA 2167351

The present invention relates to a process for the preparation of 5-substituted 2-chloropyridines of the formula (I) Image (II) in which R represents optionally substituted alkyl or aralkyl, by reaction of acetenamides of the formula (II) Image (II) in which R has the meaning indicated above R1 represents C1-C4-alkyl or aryl-C1-C4-alkyl, with Vilsmeier reagent, which is prepared by reaction of formamides of the formula (III) Image (III) in which R2 and R3 represent straight-chain, branched or cyclic C4-C8-alkyl with a chlorinating agent, the excess of which is removed from the reaction mixture by distillation or by addition of dialkylformamide after completion of the reaction of the Vilsmeier reagent with the acetenamide of the formula (II).

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