Process for the preparation of...

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C - Chemistry, Metallurgy

07

D

260/271.5

C07D 471/04 (2006.01)

Patent

CA 1050550

Process for the Preparation of Octahydrobenzocycloheptapyridiosoquinolino Derivatives Abstract of the Disclosure Octahydrobenzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-1]- isoquinolines optionally substituted at position 4 as well as positions 7 to 9 inclusive and 12 to 15 inclusive are disclosed. The compounds are prepared by a process which involves a condensation between an alkali metal salt of a 3-methyl- 1,7,8,12b-tetrahydrobenzo[1,2]cyclohepts[3,4,5-de]isoquinoline derivative and an appropriate propane compound having suitable leaving groups, for example, halogen, methylsulfonyloxy, phenylsulfonyloxy and p-toluenesulfonyloxy, at the .alpha. and .gamma. position thereon. The compounds have useful pharmacolgic and chemotherapeutic properties. Methods for their use are given. - 1 -

229360

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