Process for the preparation of 6,6-dimethyl-3-azabicyclo-...

Details Process for the preparation of 6,6-dimethyl-3-azabicyclo-... Process for the preparation of 6,6-dimethyl-3-azabicyclo-...

C - Chemistry, Metallurgy

07

D

C07D 209/54 (2006.01)

Patent

CA 2672701

The present invention provides for a process for preparing 6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate, an intermediateuseful in the efficient preparation of (1R, 2S, 5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylic acid and esters and salts thereof, processes for preparing (1R, 2S, 5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylic acid and esters and salts thereof from the sulfonate intermediate and processes for preparing 6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate.

La présente invention porte sur un procédé de préparation de 6,6-diméthyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate, un intermédiaire utile dans la préparation efficace de l'acide (1R, 2S, 5S)-méthyl 6,6-diméthyl-3-azabicyclo[3,1,0]hexane-2-carboxylique et des esters et sels de celui-ci, sur des procédés de préparation de l'acide (1R, 2S, 5S)-méthyl 6,6-diméthyl-3-azabicyclo[3,1,0]hexane-2-carboxylique et des esters et sels de celui-ci à partir de l'intermédiaire sulfonate, et sur des procédés de préparation du 6,6-diméthyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate.

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