Process for the preparation of...

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C - Chemistry, Metallurgy

07

J

260/22, 260/32

C07J 1/00 (2006.01) A61K 31/565 (2006.01) C07J 3/00 (2006.01) C07J 5/00 (2006.01) C07J 11/00 (2006.01) C07J 21/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1069117

Abstract of the Disclosure The present invention relates to a novel process for the preparation of 11.beta.-hydroxy-18-alkyl-estrene compounds by reacting an 11.beta.-hydroxy-13-methyl-gonane compound with an excess of an acylhypoiodite to give an extrano-18,11.beta.- lactone, reacting the latter compound with a Grignard compound or an alkyl lithium compound, possibly after hydrolysis of the lactone, and reducing the thus-obtained 11.beta.-hydroxy-18-alkyl-18-ketone to the corresponding 11.beta.- hydroxy-18-alkyl-estrane compound, and to novel inter- mediates of the subject compounds.

233054

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