Process for the preparation of 6alpha,9alpha-difluorinated...

Details Process for the preparation of 6alpha,9alpha-difluorinated... Process for the preparation of 6alpha,9alpha-difluorinated...

C - Chemistry, Metallurgy

07

J

C07J 1/00 (2006.01) C07J 3/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2115015

L'invention concerne un procédé de préparation des composés (I) : (Voir Formula I) où R est hydrogène ou un reste ester, au départ du composé (II) : (Voir Formula II) par dégradation oxydante, puis fluoration en 6 et fluorhydratation de l'époxyde. Les composés (I) sont connus en particulier comme anti-inflammatoires. L'invention concerne également des composés de formule (VI): (Voir Formula III) qui sont des intermédiaires de préparation desdits composés (I).

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