C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/107, 260/108
C07D 501/16 (2006.01) C07D 205/095 (2006.01) C07D 501/00 (2006.01)
Patent
CA 2026597
ABSTRACT OF THE DISCLOSURE (7-APCA) having the formula (I) Image (I) which is an important synthesis intermediate in the preparation of cephalosporin-like antibiotics, is prepared by treating a compound of the formula (II) Image (II) in which R1 and R2 represent alkyl, aryl and aralkyl radicals, with a strong protonic acid or with a Lewis acid. Compound (II) is prepared by adding triphenylphosphine and alkali metal iodide to a compound of the formula (VI) Image (VI) then reacting with acetaldehyde in base. Compound (VI) is prepared by treating a compound of the formula (VII) (VII) Image Le A 27 052 with a base in a polar solvent at -70°C to 0°C. Compound (VII) is prepared by treating a compound of the formula (VIII) (VIII) Image with a chlorinating agent in an organic solvent. Le A 27 052
Lanz Joachim
Naab Paul
Rosentreter Ulrich
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
Lanz Joachim
Naab Paul
Rosentreter Ulrich
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