Process for the preparation of 7-amino syn 3,5-dihydroxy...

Details Process for the preparation of 7-amino syn 3,5-dihydroxy... Process for the preparation of 7-amino syn 3,5-dihydroxy...

C - Chemistry, Metallurgy

07

C

C07C 227/32 (2006.01) C07C 69/67 (2006.01) C07C 69/716 (2006.01) C07C 69/732 (2006.01) C07C 69/738 (2006.01) C07C 229/22 (2006.01) C07C 235/06 (2006.01) C07C 235/74 (2006.01) C07C 253/30 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2451159

The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy- protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group ,which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy- protective group.

L'invention concerne des procédés de synthèse pour la préparation de produits intermédiaires qui sont appropriés pour la préparation de dérivés de statine, en particulier des procédés de synthèse de produits intermédiaires de formule (VI), dans laquelle R¿a? et R¿c? désignent chacun, indépendamment l'un de l'autre, l'hydrogène ou un groupe de protection hydroxy, ou forment conjointement, un pont avec groupe de protection hydroxy, et R¿b? désigne un groupe de protection carboxy, ces procédés étant mis en oeuvre par conversion du produit intermédiaire de formule (XIX) dans laquelle R¿a? et R¿c? désignent chacun, indépendamment l'un de l'autre, un hydrogène ou un groupe de protection hydroxy, et R¿b? désigne un groupe de protection carboxy.

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