Process for the preparation of 7-substituted-3-quinoline and...

Details Process for the preparation of 7-substituted-3-quinoline and... Process for the preparation of 7-substituted-3-quinoline and...

C - Chemistry, Metallurgy

07

D

C07D 215/54 (2006.01) C07D 215/22 (2006.01) C07D 215/56 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2483529

There is provided a process for the preparation of 7-substituted-3- quinolinecarbonitriles and intermediates useful in a process to prepare 7- substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatment of cancer.

Cette invention concerne un procédé de préparation de 3-quinoline carbonitriles substitués en position 7 et d'intermédiaires convenant pour la préparation de 3-quinolinecarbonitriles et des sels pharmaceutiquement acceptables de ces substances. Dans ce procédé, un 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile est transformé à l'issue de trois étapes en 3-quinolinecarbonitriles substitués en position 7 qui inhibent l'action de certaines protéines kinases et sont utiles dans le traitement du cancer.

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