Process for the preparation of 9-amino substituted...

Details Process for the preparation of 9-amino substituted... Process for the preparation of 9-amino substituted...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/554 (2006.01) A61P 25/00 (2006.01) C07D 209/00 (2006.01) C07D 281/00 (2006.01)

Patent

CA 2415050

A process is described for the preparation of compounds with the following formula where the groups are as defined below, in particular, R1 is a substituted amine, said process includes essentially the reaction of pyrrolobenzothiazepin- 9-one with amine R1H to give the corresponding enamine, which is subsequently transformed into the final compound.

L'invention porte sur un procédé de préparation de composés de formule (I) dont les groupes sont définis dans la description et où R1 en particulier est une amine substituée. Ledit procédé comporte essentiellement la réaction de la pyrrolobenzothiazépin-9-one avec l'amine R1H qui donne l'énamine correspondante qui est ensuite transformée pour donner le composé final.

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