Process for the preparation of 9-deazaguanine derivatives

Details Process for the preparation of 9-deazaguanine derivatives Process for the preparation of 9-deazaguanine derivatives

C - Chemistry, Metallurgy

07

C

C07C 13/00 (2006.01) A61K 31/519 (2006.01) A61P 17/06 (2006.01) A61P 19/06 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07C 13/465 (2006.01) C07C 13/48 (2006.01) C07C 13/615 (2006.01) C07C 15/00 (2006.01) C07C 15/12 (2006.01) C07C 15/20 (2006.01) C07C 255/30 (2006.01) C07D 207/08 (2006.01) C07D 207/10 (2006.01) C07D 207/46 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 211/60 (2006.01) C07D 211/70 (2006.01) C07D 211/82 (2006.

Patent

CA 2273983

Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound or a derivative of carbamimidoic acid to provide a protected guanidino compound. The guanidino is converted to the desired 9- deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.

On prépare des dérivés de la 9-désazaguanine en faisant réagir un aldéhyde ou une cétone avec un dialkylaminomalonate pour former l'énamine correspondante. On fait ensuite réagir l'énamine avec une base pour former un pyrrole cyclique. On fait réagir le pyrrole cyclique avec un composé ureique ou un dérivé de l'acide carbamimidoïque pour fournir un composé guanidino protégé. Le composé guanidino est converti en dérivé 9-désazaguanine par mise en réaction avec de l'acide trifluoroacétique ou avec un alcoxyde ou un hydroxyde suivi par une neutralisation avec un acide.

Affiliated with

Also associated with

Rating

Process for the preparation of 9-deazaguanine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 9-deazaguanine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 9-deazaguanine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2058464