Process for the preparation of a 3(2h)-pyridazinone-...

Details Process for the preparation of a 3(2h)-pyridazinone-... Process for the preparation of a 3(2h)-pyridazinone-...

C - Chemistry, Metallurgy

07

D

C07D 237/22 (2006.01) C07D 237/20 (2006.01)

Patent

CA 2334220

The invention relates to novel processes for the preparation of 5-chloro-4- {3- [N- [2-(3,4- dimethoxyphenyl)- ethyl]-N- methylamino]- propylamino}- 3(2H)- pyridazinone of formula (I) and the pharmaceutically acceptable acid addition salts thereof. An important feature of the invention is using 3,4,5- trichloropyridazine as starting substance for the synthesis.

L'invention se rapporte à de nouveaux procédés de préparation de 5-chloro-4- {3-[n- [-(3,4- diméthoxyphényl)- éthyl]-N- méthylamino]- propylamino}- 3(2H)- pyridazinone représenté par la formule (I) ainsi qu'aux sels d'addition acide pharmaceutiquement acceptables de ce composé. L'invention se caractérise notamment par l'utilisation de 3,4,5-trichloropyridazine en tant que produit de départ pour la synthèse ce dérivé.

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