C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 501/46 (2006.01) C07D 501/00 (2006.01)
Patent
CA 2077836
ABSTRACT The present invention provides an anhydrous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA.2 isomer comprising the N-acylation of a silylated derivative of 7-amino-3-[(1-methyl-1-pyrrolidinio)- methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.
Garofalo Elizabeth A.
Lim Gary M. F.
Roubie John M.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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