Process for the preparation of a deoxyuridine derivative

Details Process for the preparation of a deoxyuridine derivative Process for the preparation of a deoxyuridine derivative

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01)

Patent

CA 2292754

A process for the preparation of 5'-deoxy-5-fluorouridine, which comprises the transformation of 2',3'-O-isopropylidene-5-fluorouridine in the corresponding 5'-O-sulfonyl derivative, subsequent reaction with alkaline or earth-alkaline iodides and, after hydrolysis of the isopropylidene group, reduction of the 5'-deoxy-5'-iodo-5-fluorouridine thus obtained, is described.

L'invention concerne un procédé de préparation de 5'-déoxy-fluorouridine, le procédé consistant à transformer 2',3'-O-isopropylidène-5-fluorouridine en un dérivé 5'-O-sulfonyle correspondant, puis à le mettre en réaction avec des iodures alcalins ou alcalinoterreux, et après hydrolyse du groupe isopropylidène, à réduire le 5'-déoxy-5'-iodo-5-fluorouridine ainsi obtenu.

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