Process for the preparation of a growth hormone secretagogue

Details Process for the preparation of a growth hormone secretagogue Process for the preparation of a growth hormone secretagogue

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2235511

The present invention is directed to a novel process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'- piperdin]-1'-yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl- propanamide, and salts thereof, which has structure (1) and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.

La présente invention se rapporte à un nouveau procédé de préparation du composé N-[1(R)-[1,2-dihydro-1-méthanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phénylméthyloxy)éthyl]-2-amino-2-méthyl-propanamide, et de certains de ses sels, ledit composé étant représenté par la formule (1) et pouvant stimuler la libération de l'hormone de croissance naturelle ou endogène. Ce composé peut être utilisé pour traiter des états nécessitant une stimulation de la production ou de la sécrétion de l'hormone de croissance, par exemple chez des sujets humains présentant une carence en hormone de croissance naturelle ou chez des animaux utilisés pour la production alimentaire ou lainière, la stimulation de l'hormone de croissance permettant d'accroître la taille de l'animal et de le rendre plus productif.

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