C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 227/16 (2006.01) C07C 227/04 (2006.01) C07C 229/66 (2006.01)
Patent
CA 2195635
The present invention refers to a process for the preparation of 5-amino-2,4,6- triiodo-1,3-benzenedicarboxylic acid, comprising the following steps: a) catalytic hydrogenation of 5-nitro-1,3-benzenedicarboxylic acid in neutral or basic environment, which gives an aqueous solution of 5-amino-1,3-benzenedicarboxylic acid sodium salt; b) direct iodination of the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution deriving from step a), without further purification, with a solution of ICI in HCl, being the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution previously added with HCl and H2SO4.
La présente invention se rapporte à un procédé de préparation de l'acide 5-amino-2,4,6,triiodo-1,3-benzènedicarboxylique comprenant les étapes suivantes: a) l'hydrogénation catalytique de l'acide 5-nitro-1,3-benzène dicarboxylique dans un environnement neutre ou basique qui permet d'obtenir une solution aqueuse de sel de sodium de l'acide 5-amino-1,3-benzènedicarboxylique; b) l'iodation directe de la solution de sel de sodium de l'acide 5-amino-1,3-benzènedicarboxylique obtenue à l'étape a), sans purification supplémentaire, avec une solution de ICl dans HCl, la solution de sel de sodium de l'acide 5-amino-1,3-benzène dicarboxylique ayant été auparavant ajoutée avec HCl et H2SO4.
Gagna Massimo
Mauro Marina
Viscardi Carlo Felice
Bracco Imaging S.p.a.
Fructamine S.p.a.
Kirby Eades Gale Baker
LandOfFree
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