Process for the preparation of a macrocycle

Details Process for the preparation of a macrocycle Process for the preparation of a macrocycle

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2709032

The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula (VH) wherein R1 is an amino protecting group and X is halogen by way of a ring closing metathesis approach.

La présente invention concerne un nouveau procédé de préparation de composés macrocycliques inhibiteurs de la protéase du HCV de formule (VII) dans laquelle R1 est un groupe de protection amino et X est un atome d'halogène par les moyens d'une approche de métathèse par fermeture de cycle.

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